Billy Crystal
Mike (voice)

John Goodman
Sullivan (voice)

Steve Buscemi
Randy (voice)

Helen Mirren
Dean Hardscrabble (voice)

Peter Sohn
Squishy (voice)

Joel Murray
Don (voice)

Sean Hayes
Terri (voice)

Dave Foley
Terry (voice)

Charlie Day
Art (voice)

Alfred Molina
Professor Knight (voice)

Tyler Labine
Greek Council VP (voice)

Nathan Fillion
Johnny (voice)

Aubrey Plaza
Greek Council President (voice)

Bobby Moynihan
Chet (voice)

Noah Johnston
Young Mike (voice)

Julia Sweeney
Ms. Squibbles (voice)

Bonnie Hunt
Mrs. Graves (voice)

John Krasinski
Frank McCay (voice)

Bill Hader
Referee / Slug (voice)

Beth Behrs
PNK Carrie (voice)